First Evidence of the Protective Effects of 2-Pentadecyl-2-Oxazoline (PEA-OXA) in In Vitro Models of Acute Lung InjuryArticle Published on 2022-12-242023-07-11 Journal: Biomolecules [Category] COVID19(2023년), [키워드] 2-pentadecyl-2-oxazoline acute respiratory distress syndrome Anti-inflammatory endocannabinoids fibrosis Lung epithelial cells palmitoylethanolamide. [DOI] 10.3390/biom13010033 PMC 바로가기
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cellsArticle Published on 2022-11-012022-11-15 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 진단, [키워드] 16HBE 16HBE cell 16HBE cells 6-O-angeloylplenolin ACE2 ACE2 expression addition administration Cell Centipeda Centipeda minima chemokine Chinese Compound conducted COVID-19 CX3CL1 CXCL13 dataset demonstrated downregulated entry of SARS-CoV-2 enzyme evaluated expression gene encoding HLF IL-6 inhibited inhibitor Interaction lung epithelial cell Lung epithelial cells lung tissue lung tissues mice modulate parental pathogen phosphorylated positively correlated promoter PROTECT Protein pseudovirus receptor reduced regulate Regulation S protein SARS-CoV-2 SARS-COV-2 infection screened STAT3 STAT3. stimulated suppressed target cells tested TFS Transcription transcription factor transfected with [DOI] 10.1038/s41401-022-00906-6 PMC 바로가기
Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2Article Published on 2022-09-072022-11-15 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 유전자 메커니즘, 치료제, [키워드] activated addition Analysis Anti-inflammation Antiviral antiviral drug approach caused conducted coronavirus 2 COVID-19 disrupting E3 ligase E3 ubiquitin ligase effective ENhance enzyme global pandemic Health highlighting Host Infection Inflammatory responses innate immune response Innate immunity interferon lung epithelial cell Lung epithelial cells mechanism modulate multiomics pathogenesis of SARS-CoV-2 promote Protein proteomic respiratory reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein significantly Spread targets the epidemic the Spike therapeutic targets transcriptomic Vaccine viral infection [DOI] 10.1038/s41392-022-01156-y PMC 바로가기
Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patientsArticle Published on 2022-08-112022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] 95% CI adaptive immune responses Angiogenesis antiviral response antiviral responses asymptomatic infection AUROC Biomarker Biomarkers chemokines circulating miRNA clinical condition collected Combination COVID-19 COVID-19 pathogenesis COVID-19 patient DE miRNA death differentially expressed disease disease severity downregulation driven by experiment Genes healthy control heart failure highlighting Hospital admission human cell impairment in vitro induce Inflammation inhibit Innate immunity interferon involved leukocyte life threatening Lung disease Lung epithelial cells Lung fibrosis microRNA microRNA. Mild miR-4433b-5p miRNA miRNA signature miRNAs moderate modulated Mortality organ damage outcome Patient predicted pro-inflammatory cytokine pro-inflammatory factors provided RNA-sequencing SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity serum serum sample severe COVID-19 severe disease severity Stress subset the cytokine storm upregulation Vascular damage was performed with COVID-19 [DOI] 10.3389/fimmu.2022.968991 PMC 바로가기
The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor녹차 카테킨 EGCG는 범 코로나바이러스 부착 억제제에 대한 개념 증명을 제공합니다Article Published on 2022-07-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Antiviral antiviral activity attachment block catechin caused Cell conserved coronavirus Coronavirus-2 Coronaviruses CoV CoV infection COVID-19 pandemic CoVs EGCG Endemic epigallocatechin epigallocatechin gallate epithelial cells gallate glycans green tea HCoV-OC43 Health heparan sulfate heparin highlight highly pathogenic CoVs Infection inhibitor inhibitors Lentiviral particle lentiviral particles Lung epithelial cells mechanism murine Prevent PROTECT Proteoglycan provide pseudotyped rapid response reduce remained required SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Spike protein Spike proteins sulfate target cell Treatment Vaccine development virion binding virus [DOI] 10.1038/s41598-022-17088-0 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection of human-induced pluripotent stem cells-derived lung lineage cells evokes inflammatory and chemosensory responses by targeting mitochondrial pathways인간 유도 만능 줄기 세포 유래 폐 계통 세포의 SARS-CoV-2 감염은 미토콘드리아 경로를 표적으로 하여 염증 및 화학 감각 반응을 유발합니다Article Published on 2022-07-012022-09-12 Journal: Journal of cellular physiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome addition Affect airway alveolar alveolar cells Antiviral Apoptosis caused Cell cells chemosensory chemosensory response Complexes Consequences coronavirus COVID-19 COVID-19 disease COVID-19 patients Defense developmental distal dysregulation epithelial HMOX1 IL-13 IL-6 immune responses in viral in vitro Increased induced pluripotent stem cells INF-γ infected cell Inflammatory Inflammatory response Lineage lung lung epithelial Lung epithelial cells Lung injury lung tissue maturation mechanism metabolic processe mitochondrial mitochondrial damage. pathway precursor Proinflammatory cytokine proximal replicated response resulting robust ROS ROS production SARS-CoV-2 SARS-COV-2 infection spatiotemporal therapeutic drug TNF-α transcriptomics Transport upregulated upregulation [DOI] 10.1002/jcp.30755 PMC 바로가기 [Article Type] Article
Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations용도 변경 구충제 조합의 상승적 항 SARS-CoV-2 활성Article Published on 2022-06-182022-09-11 Journal: BMC Pharmacology & Toxicology [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Analysis anti-parasitic drug Anti-parasitic drugs Anti-SARS-CoV-2 Activity antiviral drug antiviral drugs approach benefit Calu Calu-3 calu-3 cells Chloroquine claimed clinical trials Combination combinations country COVID-19 pandemic demonstrated drug drug combination drug combinations drugs Economy effective Effectiveness ENhance epithelial cells evaluated Health Service highest in vitro inhibitory inhibitory concentration Ivermectin Lung epithelial cells niclosamide pandemic reduction in Repurposed drug repurposing resulting SARS-CoV-2 SARS-CoV-2. shown Spread synergistic synergy tested Treatment vaccination Vero E6 Vero E6 cell VERO E6 cells [DOI] 10.1186/s40360-022-00580-8 PMC 바로가기 [Article Type] Article
SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1SARS-CoV-2 비구조 단백질 6은 ATP6AP1을 표적으로 하여 NLRP3 의존성 발열을 유발합니다Article Published on 2022-06-012022-09-11 Journal: Cell Death and Differentiation [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] abrogated activated Activation acute respiratory syndrome coronavirus Analysis Asymptomatic COVID-19 ATP6AP1 ATPase autophagic flux binding caspase-1 coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated epithelial cells exhibited impair induce Infection Inflammasome inflammasome activation inflammasomes inflammatory cell Inflammatory cell death inhibit inhibited interleukin L37F live SARS-CoV-2 lung epithelial cell Lung epithelial cells lung tissues lysosome acidification maturation metformin Mutation NLRP3 non-structural protein NSP6 overexpression Patient pharmacological Polydatin proton pump pyroptosis receptor signaling reduced respiratory SARS-CoV-2 serological markers severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 suggested Support Transcriptome transcriptome analysis Trigger triggered upstream vacuolar variant viral pathogenicity weakened [DOI] 10.1038/s41418-021-00916-7 PMC 바로가기 [Article Type] Article
SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodiesSARS-CoV-2 숙주 차단은 타고난 NK 세포 기능에 영향을 미치지만 항체 의존적 NK 활성은 스파이크가 아닌 항체를 통해 강력하게 활성화됩니다Article Published on 2022-05-192022-09-11 Journal: eLife [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] a minor activated activating Activation ADCC ADNKA Analysis antibody Cell cellular immunity correlated cytokine dependent on Depletion Disease progression dominant downregulation Effect Efficacy epithelial cells evade expression functions genetic risk factors identify immune response Immunity immunology Impact implication infected cell Infection Infectious disease Inflammation Innate immunity interferon interferon response Ligand Lung epithelial cells mechanism membrane MHC-I MICA Microbiology minor Most patients natural infection Nectin1 neutralisation NK cell NK cells nsp1 nsp14 nucleocapsid occurred ORF3a outcome overcome Pathogenesis patients pro-inflammatory cytokine protein synthesis Proteins proteomic reduction in response SARS-CoV-2 SARS-CoV2 second dose specific antibodies spike-specific antibodies Spike-specific antibody surface protein sustained the disease ULBP2 understanding vaccination Vaccine Vaccine design vaccine efficacy Vaccine-induced immunity virus viruses viruses. [DOI] 10.7554/eLife.74489 PMC 바로가기 [Article Type] Article
Six Feet under Microbiota: Microbiologic Contamination and Toxicity Profile in Three Urban Cemeteries from Lisbon, Portugal미생물총 아래 6피트: 포르투갈 리스본의 3개 도시 공동묘지의 미생물학적 오염 및 독성 프로파일Article Published on 2022-05-162022-09-11 Journal: Toxins [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] A549 Analysis Aspergillus azole azole resistance Bacteria cemeteries Cemetery conducted Contamination cytotoxic cytotoxic effects cytotoxicity EDC Effect electrostatic environmental reservoir epithelial cells Future gram Gram-negative bacteria Health HepG2 HepG2 cells highest Lung epithelial cells management Measures media microbial molecular mycophenolic acid mycotoxins occupational health occupational health. organic matter pathogenic microorganism Pathogenic microorganisms Portugal profile ranged reached risk Risk management SARS-CoV-2 swabs Total urban [DOI] 10.3390/toxins14050348 PMC 바로가기 [Article Type] Article